Informed Girl
Informed SkinProfhilo

Biostimulators

Profhilo

Stabilised High-Concentration HA Bioremodeler

Ultra-high HA concentration remodels skin laxity without adding volume

Skin LaxityLoss of CollagenCrepey Neck
In plain English

Profhilo is a concentrated form of hyaluronic acid injected at just five points per side of the face, where it spreads widely through the tissue rather than sitting in one spot like a filler. Instead of adding volume, it improves the skin's texture, firmness, and hydration by stimulating collagen and elastin production. It's best thought of as a skin quality treatment, not a wrinkle or volume filler.

Safe for skin types
Safe forAll Fitzpatrick types I–VI
Avoid ifActive skin infection; autoimmune conditions affecting skin

PDRN and HA-based skin boosters are not melanocyte-active and do not carry pigmentation risk across skin types.

Common misconceptions
Myth

Profhilo adds volume like a filler

Reality

Profhilo is a bioremodeller, not a volumiser. It improves skin quality and laxity but does not replace structural volume. Patients expecting lifting or volume restoration will be disappointed.

Myth

Profhilo is available everywhere and FDA approved

Reality

Profhilo is CE Marked for EU and UK but does not have FDA approval. It is not legally available as a standalone product in the United States through normal clinical channels.

Myth

Because Profhilo has no BDDE cross-linking it has no risks

Reality

Delayed hypersensitivity, papule formation, and bruising are all documented with Profhilo. The absence of BDDE cross-linking reduces some risks but does not eliminate injectable HA class risks entirely.

Quick Facts
Duration6 months
Studies200+
FDA StatusCE Marked (EU/UK)
Price$700–$1,200/session

Should You Try This?

15106OUT OF 10

Probably wait for more data

Educational content only. This page summarises published clinical research and is not medical advice. Consult a qualified healthcare provider before making decisions about your care.

Researched by

Val Yermakova

Informed Girl · informedgirl.com

The Weekly Briefing

Stay informed

Every paper is individually reviewed and scored for study design, blinding, and funding independence. Educational content, not medical advice.

Subscribe for updates about the latest research. No spam.