Peptides

“Peptides are a retinoid replacement with the same evidence.”

Retinoids have hundreds of independent RCTs and FDA-cleared indications. Peptides have a fraction of that evidence base, most of it in vitro or industry-funded. They are a useful complement but not an equivalent alternative for collagen remodelling outcomes.

“More peptide types in a formula means a better product.”

Peptides have different and sometimes overlapping mechanisms. A product with ten peptide types is not necessarily more effective than one with two; formulation, concentration, delivery, and penetration enhancement matter more than ingredient count.

“Argireline is a topical Botox.”

Argireline inhibits SNARE proteins in vitro at high concentrations. At the concentrations and penetration depths achievable with topical application, the mechanism of action is not equivalent to injectable botulinum toxin, which acts at the neuromuscular junction deep to the dermis. Marketing claiming Botox-like effects is not supported by published human data.