Informed SkinHydroquinone

Products

Hydroquinone

Hydroquinone (1,4-dihydroxybenzene)

Gold-standard depigmenting agent for melasma and dark spots

HyperpigmentationDark Spots
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Sourced via EWG Skin Deep, one of the scientific databases used by the Yuka app to evaluate cosmetic ingredient safety.

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Key Study

Efficacy and Safety of Generic Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream for Moderate-To-Severe Melasma: A Randomized, Placebo-Controlled Trial

Hu H et al. · Journal of Cosmetic Dermatology · 2025

Triple combination cream (fluocinolone, hydroquinone, tretinoin) achieved significantly greater MASI score reduction vs placebo in moderate-to-severe melasma.

PubMed ↗  PMID 40296512
Quick Facts
DurationTwice daily for 8-12 weeks; cycles recommended
Studies19+
FDA StatusOTC (2%) / Rx (4%)
Price$8-$45

Full briefing coming soon.

Should You Try This?

15107OUT OF 10

Probably okay to try

Educational content only. This page summarises published clinical research and is not medical advice. Consult a qualified healthcare provider before making decisions about your care.

Researched by

Val Yermakova

Informed Girl · informedgirl.com