Skin Resurfacing
Fraxel Dual
Fractional Non-Ablative Laser (1550/1927nm)
Fractional laser targeting texture, pigmentation, and fine lines with lower downtime
Fractional non-ablative laser still carries meaningful PIH risk for medium-to-dark skin types. Studies document hyperpigmentation rates of 25–30% in Fitzpatrick IV–V at standard settings.
Fraxel works by creating thousands of tiny columns of laser energy in the skin, leaving the surrounding tissue untouched so the skin heals faster than with full ablative lasers. This approach stimulates collagen and fades pigmentation while keeping recovery time to around five days of bronzed, peeling skin rather than weeks. A series of three to five sessions produces the most meaningful results for things like acne scars, sun damage, and uneven tone.
Fraxel Dual delivers fractional non-ablative laser energy at two wavelengths, 1550nm (penetrates to mid-dermis for collagen remodelling) and 1927nm (superficial, targets pigmentation and fine texture). Each treatment creates thousands of microscopic treatment zones surrounded by untouched tissue, enabling rapid re-epithelialisation within 24 hours while still generating meaningful collagen stimulation. It occupies the "moderate efficacy, moderate downtime" space: more effective than superficial peels, significantly less downtime than full CO₂.
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Manstein et al. (Lasers Surg Med 2004), the foundational fractional photothermolysis paper, demonstrated 67% mean improvement in periorbital wrinkles at 3 months after 3 sessions, establishing fractional delivery as a meaningful advance over non-fractional non-ablative treatments.
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A systematic review of 1550nm fractional laser studies (n=847) found consistent improvements in acne scarring (mean 46% scar grade improvement) across multiple RCTs, with 2-5 days of downtime vs. 7-14 days for ablative modalities.
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Melasma response is mixed: the 1927nm wavelength improves surface pigmentation, but fractional heating can paradoxically stimulate melanocytes and worsen melasma in predisposed patients. Melasma is a relative contraindication for Fraxel.
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Graber et al. (Dermatol Surg 2008; n=961 treatments) documented a 7.6% overall adverse event rate with 1550nm fractional laser: acneiform eruptions 1.9%, herpes simplex reactivation 1.8%, prolonged erythema 0.8%, bacterial impetigo 0.3%. This rate is higher than typically communicated at point of sale.
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Herpes simplex reactivation is a confirmed risk for all fractional laser treatments. Patients with any history of cold sores should receive antiviral prophylaxis (valacyclovir or acyclovir) starting one day before treatment. Providers who do not screen for herpes history are not following standard care.
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PIH risk for Fitzpatrick III-IV skin is 5-15% even with non-ablative fractional delivery. Pre-treatment melanocyte suppression (hydroquinone or alternatives) for 4-6 weeks before the first session is the standard mitigation strategy.
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Post-treatment acneiform eruptions are documented in the Graber series and resolve within 1-2 weeks but require adjustment of post-care protocol to avoid follicular occlusion.
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Optimal treatment density and energy parameters for different indications; current protocols are largely empirical.
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Whether combining 1550 + 1927nm in a single pass provides additive benefit or simply increases downtime without proportional efficacy gain.
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Cumulative PIH risk from repeated Fraxel series over 5-10 years has not been studied in long-term follow-up trials.
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Whether the 7.6% adverse event rate from Graber et al. (2008) remains accurate with current device generations and whether adverse events are underreported in manufacturer-sponsored post-market studies.
Fractional photothermolysis: a novel aesthetic laser surgery modality
Manstein et al. · Lasers in Surgery and Medicine · 2004
The foundational fractional photothermolysis study (n=32) demonstrated that the 1550-nm erbium fibre laser creates microscopic treatment zones surrounded by undamaged tissue, enabling epidermal regeneration within 24 hours and 67% mean improvement in periorbital wrinkles after 3 treatments.
PubMed ↗ PMID 17451574| Brand | Manufacturer | What differentiates it | Approval | Pricing |
|---|---|---|---|---|
| Fraxel Dual (1550/1927) | Solta Medical | Dual-wavelength; best established evidence base for fractional non-ablative | FDA Cleared | $1,200–$2,500/session |
| Clear + Brilliant | Solta Medical | Mini-Fraxel; lower energy; no downtime; maintenance rather than correction | FDA Cleared | $400–$700/session |
| Moxi (1927nm) | Solta Medical | Superficial 1927nm only; pigmentation + tone; minimal downtime | FDA Cleared | $600–$1,200/session |
Full list of studies reviewed7 studies +
- 1.Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426-38.PMID 15216537 ↗
- 2.Rahman Z, Alam M, Dover JS. Fractional laser treatment for pigmentation and texture improvement. Skin Therapy Lett. 2006;11(9):7-11.PMID 17075674 ↗
- 3.Graber EM, Tanzi EL, Alster TS. Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatol Surg. 2008;34(3):301-5.PMID 17075654 ↗
- 4.Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg. 2007;33(3):295-9.PMID 17338686 ↗
- 5.Hasegawa T, Matsukura T, Mizuno Y, Suga Y, Ogawa H, Ikeda S. Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol. 2006;33(9):623-7.PMID 17338686 ↗
- 6.Jih MH, Kimyai-Asadi A. Fractional photothermolysis: a review and update. Semin Cutan Med Surg. 2008;27(1):63-71.PMID 16958807 ↗
- 7.Chapas AM, Brightman L, Sukal S, et al. Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med. 2008;40(6):381-6.PMID 18486026 ↗
Should You Try This?
Probably okay to try
Clinic checklist
Universal
- Check the practitioner is licensed and registered. In the UK: look them up on the GMC (doctors), NMC (nurses), or GDC (dentists) register, all free to search online. In the US: search your state medical board. Takes 2 minutes. If they cannot tell you their regulatory body, leave.
- Ask to see the product box before treatment. It should be factory-sealed with a visible lot number and expiry date. If the product arrives pre-drawn in a syringe with no packaging, you cannot verify what you are being injected with.
- You should receive a written consent form before treatment. It should name the specific product, list the known risks, and state what the clinic will do if complications arise. A single generic form with no product name is not adequate.
- A reputable clinic will ask about your current medications (especially blood thinners like aspirin, ibuprofen, warfarin), supplements (fish oil, vitamin E, ginkgo), autoimmune conditions, allergies, and past treatments. If no one asks, they are skipping a safety step.
- Before photos should be taken in consistent lighting before every session. This protects you: if a complication or asymmetry develops, both you and the clinic have a documented baseline. If a clinic does not take before photos, they are not tracking outcomes.
- Get the full cost in writing before agreeing to treatment, including follow-up visits, touch-up appointments, and what the clinic charges for managing complications. Verbal quotes are not binding.
Procedure-specific
- Ask: which wavelength combination are you using for my concern, and why? The 1550nm wavelength targets deeper collagen remodelling for scars and wrinkles. The 1927nm wavelength targets surface pigmentation and texture. The choice should be tied to your specific concern. An injector who uses the same dual-pass on everyone is not making an individualised clinical decision.
- Ask: do you screen for herpes simplex history before Fraxel, and do you prescribe antiviral prophylaxis? Herpes simplex reactivation occurs in 1 to 2 percent of fractional laser treatments without prophylaxis. All patients with any history of cold sores should receive antivirals starting one day before treatment. A clinic that does not screen for this is not following standard care.
- Ask: given my skin tone, what is my risk of post-inflammatory hyperpigmentation, and what pre-treatment do you recommend? For Fitzpatrick III and above, the published PIH rate for fractional laser is 5 to 15 percent even with non-ablative delivery. A provider who does not raise this risk when they can see your skin tone has a safety gap.
Educational content only. This page summarises published clinical research and is not medical advice. Consult a qualified healthcare provider before making decisions about your care.