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Adapalene

Adapalene (third-generation synthetic retinoid)

OTC retinoid with strong acne data and emerging anti-aging evidence

AcneFine Line WrinklesPore SizeHyperpigmentation
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Sourced via EWG Skin Deep, one of the scientific databases used by the Yuka app to evaluate cosmetic ingredient safety.

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Key Study

Adapalene 0.3% gel for the treatment of acne vulgaris: a multicenter, randomized, double-blind, vehicle-controlled study

Thiboutot DM et al. · Journal of the American Academy of Dermatology · 2006

Adapalene 0.3% gel demonstrated a 52% median reduction in total lesions at week 12, significantly outperforming vehicle (p<0.001).

PubMed ↗  PMID 18575223
Quick Facts
DurationDaily PM use; acne improvement in 4-12 weeks; anti-aging in 12-24 weeks
Studies30+
FDA StatusOTC (0.1%) / Rx (0.3%)
Price$10-$35

Full briefing coming soon.

Should You Try This?

15108OUT OF 10

Probably okay to try

Educational content only. This page summarises published clinical research and is not medical advice. Consult a qualified healthcare provider before making decisions about your care.

Researched by

Val Yermakova

Informed Girl · informedgirl.com